Translational Centre

Contact: Macdonald Ian
Phone: +44 115 823 01 19
Description:

Interests:
Human metabolism and dietary alterations in health and disease.
Fat, carbohydrate and energy metabolism, in exercise, over- and undernutrition.
Metabolic disturbances in obesity and diabetes.
Metabolic and nutritional factors affecting cognitive function.
Effects of nutrients on vascular function

Techniques:
Energy expenditure and body composition.
Hormone and metabolite assays in blood.
Metabolites and gene expression in biopsies of adipose tissue and skeletal muscle.
Measurement of whole body sensitivity to insulin, to catecholamines, and responses to single meals and dietary manipulation.
Assessing sympathoadrenal activity from plasma and urine catecholamines and microneurography of sympathetic nerves.
Non-invasive assessment of cardiovascular function.

Projects:
Dietary control of gene expression in human skeletal muscle and adipose tissue
Nutrient-gene interactions in human obesity (EU FP5).
The effects of food products on appetite, satiety and food intake (Food industry).
Dietary and lifestyle factors affecting postprandial glucose levels.
Effects of food ingredients on vascular function (Food industry)

Cognitive function
YES
Exercise capacity
YES
Metabolic and ventilator response to exercise
YES
Physical activity monitoring
YES
Cardiovascular exploration
YES
Muscle function
YES
Liver
YES
Muscle
YES
Adipose
YES
Gut
YES
Lung
NO
DEXA
YES
Bod Pod
NO
Fibroscan liver investigation
YES
Pea Pod
NO
Impedancemetry
YES
CT
NO
Ultrasound
NO
MRI
YES
Stable isotope tracers
YES
Skinfolds
YES
Test meal
YES
Dedicated kitchen
YES
Indirect calorimetry
YES
Double labelled water
YES
Calorimetric chambers
NO
Faecal analysis
NO
Clamp studies
YES
Immunology
NO
Genetics
NO
Genomics
YES
Metagenomics
NO
Biochemistry
YES
Histology
YES
Mass spectrometry
YES
Cell culture
NO
Animal models
YES
Proteomics
NO
Metabolomics
YES
Substrate turnover
YES
Nutrient biodisponiblity
YES
Obese
YES
Cardiovascular
YES
secondary prevention
Chronic respiratory disease
YES
COPD patients
Malnutrition
YES
sarcopenia ageing, cachexia in GI cancer patients
Mental disease
NO
Metabolic syndrome
YES
Gastrointestinal disease
YES
NAFLD patients
Other disease
YES
GI surgery patients
Ageing
YES
Healthy older volunteers and those with sarcopaenia
Orthopaedic
NO
Cancer
YES
Oesophageal, pancreatic
Healthy
YES
18-80y
Paediatric
NO
Diabetic
YES
Type 1 and type 2 diabetes
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