Translational Centre

Contact: Langin Dominique, Thalamas Claire
Phone: +33 561 779 103
Description:

The laboratory research on obesity explore new aspects of fatty acid metabolism in fat and muscle cells and explores the relationship between metabolic pathways and inflammatory pathways in adipose tissue. These topics are addressed by an approach that combines clinical studies in obese patients, an approach in transgenic mouse models and studies of human cell models. The laboratory has characterized the major determinants of gene expression in human adipose tissue. The studies have helped to better understand the relationship between adipocyte metabolism, macrophage immune response and fibrosis of adipose tissue. In addition, researchers have demonstrated new roles metabolic lipases, enzymes that catalyze the release of fatty acids from the lipid stocks in glucose metabolism and its control by insulin.
Expected health benefits:
The results of our projects may contribute to:
- Development Of a new classification of responses to low-calorie diets and physical activity programs
- Development Of diagnostics on the basis of gene expression profiles in adipose tissue, metabolic and hormonal responses
- Recommendations Individual programs for weight loss with an appropriate combination of caloric restriction and exercise
- Development Of new therapeutic strategies in the field of obesity and its complications

Cognitive function
YES
Exercise capacity
YES
Metabolic and ventilator response to exercise
YES
Physical activity monitoring
YES
Cardiovascular exploration
YES
Muscle function
NO
Liver
NO
Muscle
YES
Adipose
YES
Gut
NO
Lung
NO
DEXA
YES
Bod Pod
NO
Fibroscan liver investigation
NO
Pea Pod
NO
Impedancemetry
YES
CT
YES
Ultrasound
NO
MRI
NO
Stable isotope tracers
YES
Skinfolds
YES
Test meal
YES
Dedicated kitchen
YES
Indirect calorimetry
YES
Double labelled water
YES
Calorimetric chambers
NO
Faecal analysis
NO
Clamp studies
YES
Immunology
YES
Genetics
YES
Genomics
YES
Metagenomics
YES
Biochemistry
YES
Histology
YES
Mass spectrometry
YES
Cell culture
YES
Animal models
YES
Proteomics
YES
Metabolomics
YES
Substrate turnover
NO
Nutrient biodisponiblity
NO
Obese
YES
, 30-40 BMI, possibility over 50 (depends on study)
Cardiovascular
NO
Chronic respiratory disease
NO
Malnutrition
NO
Mental disease
NO
Metabolic syndrome
YES
Gastrointestinal disease
NO
Other disease
NO
Ageing
YES
healthy, obese subjects, >50 years old,
Orthopaedic
NO
Cancer
NO
Healthy
YES
18 to 80 years
Paediatric
NO
Diabetic
YES
, type 1, 2
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